Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Background Case fatality rates among African children with cerebral malaria remain in the
range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but …

Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious
infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic …

A major change in recent years has been the recognition that severe malaria, predominantly
caused by Plasmodium falciparum, is a complex multi-system disorder presenting with a …

Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge
about what actual causes CM and why certain people develop it. Although sequestration of …

Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms
underlying its development, namely how malaria-infected erythrocytes (IEs) cause disease …

Microvascular sequestration was assessed in the brains of 50 Thai and Vietnamese patients
who died from severe malaria (Plasmodium falciparum, 49; P. vivax, 1). Malaria parasites …

Cerebral malaria (CM) develops in a small proportion of persons infected with Plasmodium
falciparum and accounts for a substantial proportion of the mortality due to this parasite. The …

Conclusions The endothelium is a key organ involved in the pathogenesis of sepsis.
Dysfunction of or injury to the endothelium may be involved in the pathogenesis of multiple …