Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate
signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other …

With an epidemic spread, metabolic syndrome represents an increasingly emerging risk for
the population globally, and is currently recognized as a pathological entity. It is represented …

Coronaviruses, including SARS-CoV-2, have caused pandemics in the past two decades.
The most prevalent SARS-CoV-2 variants of concern can re-infect individuals who have …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
functions as a central hub for transmitting signals from more than 50 cytokines, playing a …

The SARS–CoV-2 infection has caused both acute and chronic COVID–19 disease during
the recent pandemic with emerging more transmissible SARS–CoV–2 Omicron variants …

Background: The outbreak of Coronavirus Disease 2019 (COVID-19) has originated from
Wuhan, China and rapidly spread all over the world. This disease is caused by a …

Background Coronavirus disease 2019 (COVID-19) is an airborne disease transmitted
primarily through respiratory droplets containing the virus. 1, 2 The causative pathogenic …

Background: The development and roll-out of vaccines, and the use of various drugs have
contributed to controlling the COVID-19 pandemic. Nevertheless, challenges such as the …

Abstract Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are severe
cutaneous adverse drug reactions, rare but life-threatening, characterized by massive …