Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Recent progress in studying copper‐dependent targets and pathways in the context of tumor
treatment has provided new insights into therapeutic strategies of leveraging copper …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Cisplatin, or cis-diamminedichloridoplatinum (II) cis-[PtCl 2 (NH 3) 2], is a platinum-based
anticancer drug largely used for the treatment of various types of cancers, including …

Recent advances in NMR methodology and techniques allow the structural investigation of
biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well …

Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …

The interactions of clinically established anticancer Pt-based drugs with proteins play crucial
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …

A critical discussion is presented about the possible role of Pt–protein interactions in the
mechanisms of action of platinum anticancer compounds. Although, since 40 years from its …

Copper (Cu) was recently demonstrated to play a critical role in cellular physiological and
biochemical processes, including energy production and maintenance, antioxidation and …