Cancer genomics research aims to advance personalized oncology by finding and targeting
specific genetic alterations associated with cancers. In genome-driven oncology, treatments …

Pioneering work by, among others, the groups of Hunt and Mann at the start of this century
opened up the era of mass spectrometry (MS)-based phosphoproteomics. 1− 3 Through …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Introduction: Numerous diseases are caused by changes in post-translational modifications
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …

Among the pleotropic roles of transforming growth factor–β (TGFβ) signaling in cancer, its
impact on genomic stability is least understood. Inhibition of TGFβ signaling increases use of …

Background: Pancreatic carcinoma (PC) is an aggressive malignancy that lacks strategies
for early detection. This study aimed to develop a coherent, high-throughput and non …

Given superior analytical features, MS proteomics is well suited for the basic investigation
and clinical diagnosis of human disease. Modern MS enables detailed functional …

Introduction: Exploring post-translational modifications (PTMs) with the use of mass
spectrometry (PTMomics) is a rapidly developing area, with methods for discovery …

Oral squamous cell carcinoma (OSCC) has become a global health problem due to its
increasing incidence and high mortality rate. Early intervention through monitoring of the …

Immunotherapies are revolutionizing cancer care, producing durable responses and
potentially cures in a subset of patients. However, response rates are low for most tumors …