Body temperature regulation is a fundamental homeostatic function that is governed by the
central nervous system in homeothermic animals, including humans. The central …

The adipocyte-derived hormone leptin is a peripheral signal that informs the brain about the
metabolic status of an organism. Although traditionally viewed as an appetite-suppressing …

Objective Leptin responsive neurons play an important role in energy homeostasis,
controlling specific autonomic, behavioral, and neuroendocrine functions. We have …

Brown adipose tissue (BAT) thermogenesis is critical to maintain homoeothermia and is
centrally controlled via sympathetic outputs. Body temperature and BAT activity also impact …

The central autonomic network includes the insular cortex, anterior cingulate cortex,
amygdala, hypothalamus, periaqueductal gray, parabrachial nucleus, nucleus of the solitary …

The preoptic area (POA) is a key brain region for regulation of body temperature (Tb),
dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previously …

This study aimed at determining the thermoregulatory phenotype of mice lacking transient
receptor potential vanilloid-1 (TRPV1) channels. We used Trpv1 knockout (KO) mice and …

Psychological stress elicits increases in sympathetic activity accompanied by a marked
cardiovascular response. Revealing the relevant central mechanisms involved in this …

To maintain energy homeostasis during cold exposure, the increased energy demands of
thermogenesis must be counterbalanced by increased energy intake. To investigate the …

Within the central neural circuitry for thermoregulation, the balance between excitatory and
inhibitory inputs to the dorsomedial hypothalamus (DMH) determines the level of activation …