Abstract Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins
predominantly known for the regulation of caspases and immune signaling. However, recent …

How do cells age and die? For the past 20 years, the budding yeast, Saccharomyces
cerevisiae, has been used as a model organism to uncover the genes that regulate lifespan …

Background Qualitative frameworks, especially those based on the logical discrete
formalism, are increasingly used to model regulatory and signalling networks. A major …

Background A key problem in the analysis of mathematical models of molecular networks is
the determination of their steady states. The present paper addresses this problem for …

Regulation of the cell cycle and apoptosis are two eukaryotic processes required to ensure
maintenance of genomic integrity, especially in response to DNA damage. The ease with …

In this paper, two pinning control (PC) schemes are proposed to achieve non-periodical
stable behaviors for asynchronous Boolean networks (BNs), from the aspects of state …

This paper formulates a compositional method to alleviate the high computational cost of
studying large-scale Boolean networks (BNs). The algebraic expression of conjunctive …

Hair follicles (HFs) are mini skin organs that undergo cyclic growth. Various signals regulate
HF cell fate decisions jointly. Recent experimental results suggest that transforming growth …

One of the ultimate goals in systems biology is to develop control strategies to find efficient
medical treatments. One step towards this goal is to develop methods for changing the state …

A Boolean model is a simple, discrete and dynamic model without the need to consider the
effects at the intermediate levels. However, little effort has been made into constructing …