Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …

Acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) is one
of the largest and most devastating public health pandemics throughout the world. The …

The chemistry of quinolones, representing one of the major classes of nitrogen-containing
heterocyclics, has received more attention and considered one of the promising …

The oxadiazole core is considered a privileged moiety in many medicinal chemistry
applications. The oxadiazole class includes 1, 2, 3-oxadiazole, 1, 2, 4-oxadiazole, 1, 3, 4 …

Three α-aminophosphonates, namely diethyl [(5-phenyl-1, 3, 4-oxadiazol-2-ylamino)(4-
trifluoromethylphenyl) methyl] phosphonate (3a), diethyl [(5-phenyl-1, 3, 4-oxadiazol-2 …

Due to their diverse applications in industrial and synthetic organic chemistry, quinoline and
1, 3, 4-oxadiazole have become important heterocyclic compounds. Quinoline and 1, 3, 4 …

Background: The emergence of drug-resistant viral strains has created the need for the
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …

The significant threat to humanity is HIV infection, and it is uncertain whether a definitive
treatment or a safe HIV vaccine is. HIV-1 is continually evolving and resistant to commonly …

Design, Synthesis, Molecular Modeling, In Silico ADME Studies and Anti-HIV-1 Assay of New
Diazocoumarin Derivatives - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Background: Although major efforts have been devoted to the effective treatment of HIV-1
infection, it has remained one of the leading causes of deaths around the world. So …