Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP)

A Zufferey, R Kapur, JW Semple - Journal of clinical medicine, 2017 - mdpi.com
Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Cellular immune dysfunction in immune thrombocytopenia (ITP)

CGJ McKenzie, L Guo, J Freedman… - British journal of …, 2013 - Wiley Online Library
Over the past decades, a wealth of information has been reported about the pathogenic
features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the …

Platelets fuel the inflammasome activation of innate immune cells

V Rolfes, LS Ribeiro, I Hawwari, L Böttcher, N Rosero… - Cell reports, 2020 - cell.com
The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin
(IL)-1 family. The inflammasome assembled by NLRP3 has been predominantly studied in …

Pathogenesis in immune thrombocytopenia: new insights

J Johnsen - Hematology 2010, the American Society of …, 2012 - ashpublications.org
Idiopathic (immune) thrombocytopenic purpura (ITP) is a common autoimmune disorder
resulting in isolated thrombocytopenia. ITP can present either alone (primary) or in the …

Aplastic anemia: pathophysiology

V Giudice, C Selleri - Seminars in Hematology, 2022 - Elsevier
Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological
conditions characterized by uni-or multi-lineage marrow and/or peripheral blood cytopenia …

Alterations in hematologic indices during long-duration spaceflight

H Kunz, H Quiriarte, RJ Simpson, R Ploutz-Snyder… - BMC hematology, 2017 - Springer
Background Although a state of anemia is perceived to be associated with spaceflight, to
date a peripheral blood hematologic assessment of red blood cell (RBC) indices has not …

Current understanding of immune thrombocytopenia: a review of pathogenesis and treatment options

A Mititelu, MC Onisâi, A Roșca… - International Journal of …, 2024 - mdpi.com
The management of immune thrombocytopenia (ITP) and the prediction of patient response
to therapy still represent a significant and constant challenge in hematology. ITP is a …

Aplastic anemia, cellular and molecular aspects

MR Javan, N Saki… - Cell Biology …, 2021 - Wiley Online Library
Aplastic anemia (AA) is an autoimmune disorder characterized by bone marrow and
peripheral blood pancytopenia. Different environmental and genetical conditions could be …

Treatment with Evasin‐3 abrogates neutrophil‐mediated inflammation in mouse acute pancreatitis

F Montecucco, F Mach, S Lenglet… - European journal of …, 2014 - Wiley Online Library
Background Acute pancreatitis is characterized by inflammatory processes affecting not only
the pancreas, but also the lung. Here, we investigated timing of leucocyte infiltration and …

Ticagrelor improves endothelial function by decreasing circulating epidermal growth factor (EGF)

F Vieceli Dalla Sega, F Fortini, G Aquila… - Frontiers in …, 2018 - frontiersin.org
Ticagrelor is one of the most powerful P2Y12 inhibitor. We have recently reported that, in
patients with concomitant Stable Coronary Artery Disease (SCAD) and Chronic Obstructive …