Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief
statement, the possible contribution of nuclear architecture studies to the field of …

Imaging single fluorescent proteins in living mammalian cells is challenged by out-of-focus
fluorescence excitation. To reduce out-of-focus fluorescence we developed reflected light …

The architecture of human chromosomes in interphase nuclei is still largely unknown.
Microscopy studies have indicated that specific regions of chromosomes are located in close …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

The factors that sequester transcriptionally repressed heterochromatin at the nuclear
periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of …

We show that the nuclear architecture of rod photoreceptor cells differs fundamentally in
nocturnal and diurnal mammals. The rods of diurnal retinas possess the conventional …