Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Pancreatic islets are mini-organs composed of hundreds or thousands of ɑ, β and δ-cells,
which, respectively, secrete glucagon, insulin and somatostatin, key hormones for the …

Diabetes is caused by the inability of electrically coupled, functionally heterogeneous β-cells
within the pancreatic islet to provide adequate insulin secretion. Functional networks have …

Remarkable advances in protocol development have been achieved to manufacture insulin-
secreting islets from human pluripotent stem cells (hPSCs). Distinct from current …

Genetically encoded voltage indicators (GEVIs) allow the direct visualization of cellular
membrane potential at the millisecond time scale. Among these, red-emitting GEVIs have …

The mechanisms accounting for the functional changes of α-and β-cells over the course of
type 1 diabetes (T1D) development are largely unknown. Permitted by our established …

Oscillations in insulin secretion, driven by islet Ca2+ waves, are crucial for glycemic control.
Prior studies, performed with single-plane imaging, suggest that subpopulations of …

Long lagging behind insulin, glucagon research has caught up in large part, thanks to
technological breakthroughs. Here we review how the field was propelled by the …

Glucagon is secreted by pancreatic α-cells to counteract hypoglycaemia. How glucose
regulates glucagon secretion remains unclear. Here, using mouse islets, we studied the role …

Aim Somatostatin from pancreatic δ‐cells is a paracrine regulator of insulin and glucagon
secretion, but the release kinetics and whether secretion is altered in diabetes is unclear …