• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background—Infective endocarditis is a potentially lethal disease that has undergone major
changes in both host and pathogen. The epidemiology of infective endocarditis has become …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

Infective endocarditis is defined by a focus of infection within the heart and is a feared
disease across the field of cardiology. It is frequently acquired in the health care setting, and …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through November 2012, and other …

Infective endocarditis (IE), initially described more than 350 years ago, involves infection of
the endocardial surface of the heart. The clinical manifestations of IE can involve every …

Potential Biases Most studies of IE are affected by selection, survival, and referral bias. They
make it difficult to study the natural history of IE in the general population, because treated …

Despite improvements in medical and surgical therapies, infective endocarditis is associated
with poor prognosis and remains a therapeutic challenge. Many factors affect the outcome of …