Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Background Nod‐like receptor family pyrin domain‐containing protein‐3 (NLRP3) complex
inflammasome has potentially been shown to play an important role in the development of …

Aim: This study aims to identify pyroptosis-related genes (PRGs), their functional immune
characteristics, and distinct pyroptosis-related clusters in periodontitis. Methods …

Periodontitis is an immune inflammatory disease that leads to progressive destruction of
bone and connective tissue, accompanied by the dysfunction and even loss of periodontal …

The dance between microbes and the immune system takes place in all biological systems,
including the human body, but this interaction is especially complex in the primary gateway …

Purpose Periodontitis is a major chronic oral disease that is accelerated by activation of the
NLRP3 inflammasome and the resulting pyroptosis. According to recent studies, active …

Diabetes mellitus is a main risk factor for periodontitis, but until now, the underlying
molecular mechanisms remain unclear. Diabetes can increase the pathogenicity of the …

Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …

Inflammasomes are intracellular protein complexes that form in response to a variety of
stress signals and that serve to catalyze the proteolytic conversion of pro-interleukin-1β and …