An overview of spirooxindole as a promising scaffold for novel drug discovery
LM Zhou, RY Qu, GF Yang - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …
Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020
E Roshdy, M Mustafa, AER Shaltout… - European Journal of …, 2021 - Elsevier
Abstract Sirtuin 2 (SIRT2) is a member of the human sirtuins, which regulates various
biological processes and is deemed as a novel biomarker for different cancers. Depending …
biological processes and is deemed as a novel biomarker for different cancers. Depending …
Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies
OH Abdelhafez, TFS Ali, JR Fahim… - International journal …, 2020 - Taylor & Francis
Background Soft corals have been endorsed as a plentiful source of bioactive compounds
with promising anti-inflammatory activities; therefore, exploring their potential as source of …
with promising anti-inflammatory activities; therefore, exploring their potential as source of …
In vitro and in silico evaluation of anticancer activity of new indole-based 1, 3, 4-oxadiazoles as EGFR and COX-2 inhibitors
Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …
targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1 H-indol-3-yl) …
Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs
Literature conclusively shows that one of the quinolinequinone analogs (6-anilino-5, 8-
quinolinequinone), referred to as LY83583 hereafter, an inhibitor of guanylyl cyclase, was …
quinolinequinone), referred to as LY83583 hereafter, an inhibitor of guanylyl cyclase, was …
Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast …
Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer
chain acyl groups from post-translationally modified lysine residues. It affects diverse …
chain acyl groups from post-translationally modified lysine residues. It affects diverse …
Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs
Quinone-based small molecules are the promising structures for antiproliferative drug
design and can induce apoptosis in cancer cells. Among them, one of the …
design and can induce apoptosis in cancer cells. Among them, one of the …
Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy
The relentless pursuit of novel therapeutic agents against cancer has led to the identification
of multiple molecular targets, among which Sirtuin 2 (SIRT2) has garnered significant …
of multiple molecular targets, among which Sirtuin 2 (SIRT2) has garnered significant …
Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement
S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer
activity owing to its potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two …
activity owing to its potent inhibitory effect on human mitotic kinesin Eg5. STLC contains two …
A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity
Herein, we report the synthesis and cytotoxic effects of novel chlorinated plastoquinone
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …