Tuberculosis (TB) infection caused by Mycobacterium tuberculosis (Mtb) is still a persistent
global health problem, particularly in developing countries. The World Health Organization …

Tuberculosis (TB) is the primary cause of death by a single infectious agent; responsible for
around two million deaths in 2016. A major virulence factor of TB is the ability to enter a …

Highlights•Isocitrate lyase (ICL) is essential to growth and survival of Mycobacterium
tuberculosis (Mtb).•ICL is involved in Mtb glyoxylate and methylisocitrate cycles, and may …

Tuberculosis (TB) is currently the number one killer among infectious diseases worldwide.
Lipids are abundant molecules during the infectious cycle of Mycobacterium tuberculosis …

The capacity of Mycobacterium tuberculosis (Mtb) to sense, respond and adapt to a variable
and hostile environment within the host makes it one of the most successful human …

Mycobacterium tuberculosis (Mtb) survives and replicates within host macrophages (MΦ)
and subverts multiple antimicrobial defense mechanisms. Previously, we reported that lipids …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, encounters variable
and hostile environments within the host. A major component of these hostile conditions is …

Immune responses to parasitic pathogens are affected by the host physiological condition.
High-density lipoprotein (HDL) and low-density lipoprotein (LDL) are transporters of lipids …

Many studies have identified host-derived lipids, characterised by the abundance of
cholesterol, as a major source of carbon nutrition for Mycobacterium tuberculosis during …

Combination therapy is necessary to treat tuberculosis to decrease the rate of disease
relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently …