Short chain fatty acids: microbial metabolites for gut-brain axis signalling

KJ O'Riordan, MK Collins, GM Moloney… - Molecular and Cellular …, 2022 - Elsevier
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …

Advancing human gut microbiota research by considering gut transit time

N Procházková, G Falony, LO Dragsted, TR Licht… - Gut, 2023 - gut.bmj.com
Accumulating evidence indicates that gut transit time is a key factor in shaping the gut
microbiota composition and activity, which are linked to human health. Both population-wide …

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations

M Van de Wouw, M Boehme, JM Lyte… - The Journal of …, 2018 - Wiley Online Library
Key points Chronic (psychosocial) stress changes gut microbiota composition, as well as
inducing behavioural and physiological deficits. The microbial metabolites short‐chain fatty …

Pathophysiology of irritable bowel syndrome

GJ Holtmann, AC Ford, NJ Talley - The lancet Gastroenterology & …, 2016 - thelancet.com
Traditionally, irritable bowel syndrome has been considered to be a disorder with no known
underlying structural or biochemical explanation, but this concept is likely to be outdated. In …

Fecal microbiota transplantation reduces symptoms in some patients with irritable bowel syndrome with predominant abdominal bloating: short-and long-term results …

T Holvoet, M Joossens, JF Vázquez-Castellanos… - Gastroenterology, 2021 - Elsevier
Background & Aims Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder
associated with intestinal dysbiosis. Given the reported promising results of open-label fecal …

Gut microbiota-derived metabolites in irritable bowel syndrome

L Xiao, Q Liu, M Luo, L Xiong - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and
is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota …

Small intestinal bacterial overgrowth—pathophysiology and its implications for definition and management

D Bushyhead, EMM Quigley - Gastroenterology, 2022 - Elsevier
The concept of small intestinal bacterial overgrowth (SIBO) arose in the context of
maldigestion and malabsorption among patients with obvious risk factors that permitted the …

The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS

HM Staudacher, K Whelan - Gut, 2017 - gut.bmj.com
There is an intensifying interest in the interaction between diet and the functional GI
symptoms experienced in IBS. Recent studies have used MRI to demonstrate that short …

Beneficial effect of butyrate‐producing Lachnospiraceae on stress‐induced visceral hypersensitivity in rats

J Zhang, L Song, Y Wang, C Liu… - Journal of …, 2019 - Wiley Online Library
Abstract Background and Aim Emerging evidence indicates that psychological stress is
involved in the pathogenesis of irritable bowel syndrome, which is characterized by visceral …

[HTML][HTML] Pathophysiology of functional gastrointestinal disorders: a holistic overview

G Holtmann, A Shah, M Morrison - Digestive Diseases, 2018 - karger.com
Abstract Background and Summary: Traditionally, functional gastrointestinal disorders
(FGID), including functional dyspepsia or irritable bowel syndrome (IBS), are defined by …