In this review, we describe recent empirical and theoretical work on the extent of linkage
disequilibrium (LD) in the human genome, comparing the predictions of simple population …

There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans
and other species. Characterizing LD is of central importance for gene-mapping studies and …

Approximately 70 percent of the mutations in cystic fibrosis patients correspond to a specific
deletion of three base pairs, which results in the loss of a phenylalanine residue at amino …

The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in …

Haplotype-based methods offer a powerful approach to disease gene mapping, based on
the association between causal mutations and the ancestral haplotypes on which they …

Mitochondrial DNAsfrom 147 people, drawn from five geographic populations have been
analysed by restriction mapping. All these mitochondrial DMAs stem from one woman who is …

In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …

Common genetic polymorphisms may explain a portion of the heritable risk for common
diseases. Within candidate genes, the number of common polymorphisms is finite, but direct …

Abstract Analysis of linkage disequilibrium D among restriction sites or bases in DNA
sequences, arising from mutations in finite populations, depends on a knowledge of the …

Five different measures of gametic disequilibrium in current use and a new one based on
RC Lewontin's D′, are examined and compared. All of them, except the measure based on …