[HTML][HTML] Thrombotic thrombocytopenic purpura: pathophysiology, diagnosis, and management

S Sukumar, B Lämmle, SR Cataland - Journal of clinical medicine, 2021 - mdpi.com
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy
characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and …

Thrombotic thrombocytopenic purpura

JA Kremer Hovinga, P Coppo, B Lämmle… - Nature reviews Disease …, 2017 - nature.com
Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Clinical and laboratory diagnosis of TTP: an integrated approach

T Chiasakul, A Cuker - Hematology 2014, the American Society …, 2018 - ashpublications.org
Thrombotic thrombocytopenia purpura (TTP) is a rare, life-threatening disease with an
incidence of approximately 2 persons per million per year. It is characterized by severe …

Atypical hemolytic‐uremic syndrome: an update on pathophysiology, diagnosis, and treatment

R Raina, V Krishnappa, T Blaha, T Kann… - Therapeutic …, 2019 - Wiley Online Library
Atypical hemolytic uremic syndrome (aHUS), a rare variant of thrombotic microangiopathy, is
characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal …

[HTML][HTML] Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience

P Coppo, M Schwarzinger, M Buffet, A Wynckel… - PloS one, 2010 - journals.plos.org
Severe ADAMTS13 deficiency occurs in 13% to 75% of thrombotic microangiopathies
(TMA). In this context, the early identification of a severe, antibody-mediated, ADAMTS13 …

Regional UK TTP registry: correlation with laboratory ADAMTS 13 analysis and clinical features

M Scully, H Yarranton, R Liesner… - British journal of …, 2008 - Wiley Online Library
Thrombotic thrombocytopenic purpura (TTP) is an acute, rare, life‐threatening disorder. This
report presents the South East (SE) England registry for TTP, from April 2002 to December …

Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS‐13

M Scully, H Cohen, J Cavenagh… - British journal of …, 2007 - Wiley Online Library
Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder and plasma
exchange (PEX) remains the primary treatment modality. Twenty‐five patients with acute …

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission.

F Peyvandi, S Lavoretano, R Palla, HB Feys… - …, 2008 - research.unipd.it
BACKGROUND: From 20 to 50% of patients who survive an acute episode of the acquired
form of thrombotic thrombocytopenic purpura relapse but clinical and laboratory markers of …

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

E Roose, AS Schelpe, E Tellier… - Blood, The Journal …, 2020 - ashpublications.org
Recently, we showed that ADAMTS13 circulates in an open conformation during the acute
phase of immune-mediated thrombotic thrombocytopenic purpura (iTTP). Although the …

Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura

F Alwan, C Vendramin… - Blood, The Journal …, 2017 - ashpublications.org
Immune-mediated thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder
caused by antibodies against ADAMTS13. From the United Kingdom TTP registry, we …