Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Therapeutic potential of mesenchymal stem cells for cancer therapy

A Hmadcha, A Martin-Montalvo, BR Gauthier… - … in bioengineering and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for
regenerative medicine. A large number of studies have shown the beneficial effects of MSC …

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

CC Chen, L Liu, F Ma, CW Wong, XE Guo… - Cellular and molecular …, 2016 - Springer
The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …

Immunobiology of mesenchymal stem cells

S Ma, N Xie, W Li, B Yuan, Y Shi, Y Wang - Cell Death & Differentiation, 2014 - nature.com
Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively
expanded in vitro. Although their true in situ properties and biological functions remain to be …

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

K Schepers, EM Pietras, D Reynaud, J Flach… - Cell stem cell, 2013 - cell.com
Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are
part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) …

Mesenchymal stem cells in health and disease

A Uccelli, L Moretta, V Pistoia - Nature reviews immunology, 2008 - nature.com
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …

Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

MB Murphy, K Moncivais, AI Caplan - Experimental & molecular …, 2013 - nature.com
Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into
tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and …

Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing

G Chamberlain, J Fox, B Ashton, J Middleton - Stem cells, 2007 - academic.oup.com
MSCs are nonhematopoietic stromal cells that are capable of differentiating into, and
contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle …

[HTML][HTML] Mesenchymal stem cell homing: the devil is in the details

JM Karp, GSL Teo - Cell stem cell, 2009 - cell.com
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to
promote regeneration of damaged tissue, to treat inflammation, and to promote …

Mesenchymal stromal cells: current understanding and clinical status

HK Salem, C Thiemermann - Stem cells, 2010 - academic.oup.com
Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of
pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the …