To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Abstract The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™),
vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile …

Pulmonary hypertension (PH) is a clinical and pathophysiological syndrome caused by
changes in pulmonary vascular structure or function that results in increased pulmonary …

MicroRNAs (miRNAs) have emerged as a novel class of endogenous, small, noncoding
RNAs that negatively regulate gene expression via degradation or translational inhibition of …

We have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor sildenafil (Viagra)
induces a powerful effect on reduction of infarct size following ischemia/reperfusion injury …

Phosphodiesterase type 5A (PDE5A) selectively hydrolyzes cyclic GMP. Inhibitors of PDE5A
such as sildenafil are widely used to treat erectile dysfunction, but growing evidence …

We tested the hypothesis that chronic treatment with sildenafil attenuates myocardial
infarction (MI)-induced heart failure. Sildenafil has potent protective effects against necrosis …

Abstract Introduction Ischemia/reperfusion (I/R) injury, such as myocardial infarction, stroke,
and peripheral vascular disease, has been recognized as the most frequent causes of …

OBJECTIVES: Impotence, specifically corporal veno-occlusive dysfunction (CVOD), occurs
after radical prostatectomy. It results from the effects of cavernosal nerve damage, which …