The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …

Rationale: Arterial inflammation manifested as atherosclerosis is the leading cause of
mortality worldwide. Genome-wide association studies have identified a prominent role of …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging.
Soluble receptor-based strategies are not established for chemokine receptors due to their …

Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that
play key roles in inflammation and cancer. Current strategies to develop small molecule …

Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …

Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …

Neddylation plays a vital role in post-translational modification, intricately shaping the
regulation of diverse biological processes, including those related to cellular immune …

Neddylation is a ubiquitin-like post-translational protein modification. It occurs via the
activation of the neural precursor cell expressed, developmentally downregulated protein 8 …