Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

Glucose-6-phosphatase (G6Pase), an enzyme found mainly in the liver and the kidneys,
plays the important role of providing glucose during starvation. Unlike most phosphatases …

The true prevalence and penetrance of monogenic disease variants are often not known
because of clinical-referral ascertainment bias. We comprehensively assess the penetrance …

The liver plays a unique role in controlling carbohydrate metabolism by maintaining glucose
concentrations in a normal range over both short and long periods of times. In type 2 …

Conversion of glucose into glycogen is a major pathway that contributes to the removal of
glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the …

Hepatic glycogen is replenished during the absorptive period postprandially. This repletion
is prompted partly by an increased hepatic uptake of glucose by the liver, partly by …

Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK).
GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of …

Type 2 diabetes develops in the context of both insulin resistance and β-cell failure.
Thiazolidinediones are a class of antidiabetic agents that are known to improve insulin …

The traditional experimental approaches used for changing the flux or the concentration of a
particular metabolite of a metabolic pathway have been mostly based on the inhibition or …

Mutations in the glucokinase (GK) gene cause two different diseases of blood glucose
regulation: maturity onset diabetes of the young, type 2 (MODY-2) and persistent …