In this paper, we provide an overview and analysis of the BRAIN Initiative data-sharing
ecosystem. First, we compare and contrast the characteristics of the seven BRAIN Initiative …

This article reviews evolving legal implications for clinicians and researchers as genomics is
used more widely in both the clinic and in translational research, reflecting rapid changes in …

Germline genetic testing for inherited cancer risk has shifted to multi-gene panel tests
(MGPTs). While MGPTs detect more pathogenic variants, they also detect more variants of …

Sharing cancer gene variant and relevant clinical data could accelerate progress in cancer
genomics. However, data sharing is currently impeded by issues related to financial …

In 2011, the US National Academies published a report that called for an “Information
Commons” and “Knowledge Network” to enhance understanding of disease and normal …

Liability implications of direct-to-consumer genetic testing/Gary E. Marchant, Mark Barnes,
Ellen W. Clayton, and Susan M. Wolf--Consuming genetics as a life insurance …

Genetic testing for inherited cancer risk changed dramatically when the US Supreme Court
handed down unanimous rulings in Mayo v. Prometheus (2012) and Myriad v. Association …

Objectives Real-world data evaluating how approvals of novel treatment regimens for
ovarian cancer have impacted the treatment paradigm, including first-line maintenance, are …

Patient engagement in clinical research refers to the involvement of patients beyond the role
of research subject. To date, the goals of patient engagement have not been clearly defined …

Abstract The recent Food and Drug Administration (FDA) marketing authorizations granted
for testing mutations associated with hereditary breast and colon cancer, as well as …