Epithelial-to-mesenchymal transition (EMT) involving injured epithelial cells plays an
important role in the progression of fibrosis in the kidney. Tubular epithelial cells can acquire …

Recently, the first clinical reports on bone regeneration by two recombinant human bone
morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Development of the mammalian kidney is initiated by ingrowth of the ureteric bud into the
metanephric blastema. In response to signal (s) from the ureter, mesenchymal cells …

Vascular calcification is a common problem among the elderly and those with chronic kidney
disease (CKD) and diabetes. The process of tunica media vascular calcification in CKD …

In response to mechanical forces and the aging process, bone in the adult skeleton is
continuously remodeled by a process in which old and damaged bone is removed by bone …

In the kidney, a unique plasticity exists between epithelial and mesenchymal cells. During
kidney development, the metanephric mesenchyme contributes to emerging epithelium of …

BMP7 is expressed at diverse sites in the developing mouse embryo, including visceral
endoderm, notochord, heart, eye, kidney, and bone. A null mutation in BMP7 results in …

Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to
control the progression of renal fibrosis toward end-stage renal failure are limited. Previous …

We have shown that osteogenic protein-1 (OP-1)(bone morphogenetic protein-7) is
responsible for the induction of nephrogenic mesenchyme during embryonic kidney …