A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …

The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Preventing transmission is an important element of malaria control. However, most of the
current available methods to assay for malaria transmission blocking are relatively low …

Spread of parasite resistance to artemisinin threatens current frontline antimalarial
therapies, highlighting the need for new drugs with alternative modes of action. Since only …

Malaria remains a major global health challenge. Appropriate use of current antimalarial
tools has reduced the disease burden, but morbidity and mortality remain unacceptably …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Phenotypic high-throughput screens are a valuable tool for identifying new chemical
compounds with antimalarial activity. Traditionally, these screens have focused solely on the …

K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium
falciparum malaria that threatens the long-term clinical utility of artemisinin-based …