Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Abstract ToppGene Suite (http://toppgene. cchmc. org; this web site is free and open to all
users and does not require a login to access) is a one-stop portal for (i) gene list functional …

Motivation: Understanding the association between genetic diseases and their causal genes
is an important problem concerning human health. With the recent influx of high-throughput …

Background Although most of the current disease candidate gene identification and
prioritization methods depend on functional annotations, the coverage of the gene functional …

Motivation: Understanding the role of genetics in diseases is one of the most important aims
of the biological sciences. The completion of the Human Genome Project has led to a rapid …

To target complex, multi-factorial diseases more effectively, there has been an emerging
trend of multi-target drug development based on network biology, as well as an increasing …

The recently proposed concept of molecular connectivity maps enables researchers to
integrate experimental measurements of genes, proteins, metabolites, and drug compounds …

The genomic era has been characterised by vast amounts of data from diverse sources,
creating a need for new tools to extract biologically meaningful information. Bioinformatics is …

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …