Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

The transcription factor RUNX2 (Cbfa1/AML3/Pebp2αA) is a critical regulator of osteoblast
differentiation. We investigated the effect of the inflammatory cytokine tumor necrosis factor α …

Bone marrow derived mesenchymal stem cells (BM-MSCs) belong a type of pluripotent stem
cells and can be induced to differentiate into osteoblasts (OB). Runt-related transcription …

Intramuscular injection of BMP-2 induces ectopic bone formation in vivo. Similarly, BMP-2
treatment blocks myogenic differentiation and induces osteoblastic transdifferentiation of …

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

The identification of Runx2 (runt‐related protein 2) function has greatly advanced the
understanding of skeletal development over the last 5 years. Runx2 is regulated …