Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT signaling
pathway are hallmarks of prostate cancer (PCa). However, these alterations alone are …

The problem of underfitting and overfitting in machine learning is often associated with a
bias-variance trade-off. The underfitting most clearly manifests in the tree-based inducers …

The tetraspanin (TSPAN) family constitutes a poorly explored family of membrane receptors
involved in various physiological processes, with relevant roles in anchoring multiple …

Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate
cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K/AKT pathway …

The HOX genes are a group of highly conserved Homeobox‐containing genes that control
the body plan organization during development. However, their contributions to …

Current evidence indicate that cancer-associated fibroblasts (CAFs) play an important role in
prostate cancer (PCa) development and progression. In this study, we identified CAF-related …

The incidence and mortality of breast cancer rank first among all types of female tumors. To
improve patients' prognosis with advanced breast cancer, new and more effective targets …

Cell migration drives cell invasion and metastatic progression in prostate cancer and is a
major cause of mortality and morbidity. However the mechanisms driving cell migration in …

Background The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across
several cancer types; however, the effects of mutations on epigenome organization, gene …

Simple Summary Therapy resistance in head and neck squamous cell carcinoma (HNSCC)
patients is the main obstacle to achieve more effective treatments that improve survival and …