Clinical pharmacokinetics of levodopa and relevant add-on therapies for Parkinson's disease

T Müller - Expert Opinion on Drug Metabolism & Toxicology, 2024 - Taylor & Francis
Introduction Parkinson's disease is a chronic neurodegenerative disease entity
characterized by heterogeneity of symptoms and progression. Levodopa is an efficacious …

Adverse event profiles of adjuvant treatment with opicapone in Parkinson's disease: A systematic review and meta-analysis

L Xie, X Qi, X Wang, B He, Y Wang, W Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Opicapone, a novel third-generation catechol-O-methyltransferase inhibitor,
has demonstrated efficacy in Parkinson's Disease (PD) patients with end-of-dose motor …

Neuroprotection and disease modification in Parkinson's disease: Volume II

M Otero-Losada, P Gubellini, F Capani… - Frontiers in …, 2023 - frontiersin.org
Parkinson's disease (PD) is the second prevailing neurodegenerative disease worldwide
after Alzheimer's. Nearly 1% of seniors over 65 suffer from this disease, and as old …

[PDF][PDF] Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos.

CÁC Palacio - 2024 - repositorio.uniandes.edu.co
La Enfermedad de Parkinson (EP) es un trastorno neurodegenerativo relacionado con la
pérdida de neuronas en la sustancia negra pars compacta (SNpc) del mesencéfalo, con la …

Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos

CA Cárdenas Palacio - 2024 - repositorio.uniandes.edu.co
Este estudio ha pretendido determinar si se presentan cambios en la percepción del
volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor …

[HTML][HTML] Efficacy and Safety of Safinamide vs Opicapone as Adjuvant to Levodopa Therapy in Elderly with Parkinson's Disease: A Network Meta-Analysis

FM Aldian, MV Ariyanto… - Journal of Asian …, 2023 - jamsa.amsa-international.org
Introduction: Parkinson's disease (PD) becomes a significant health problem in the elderly.
This chronic and progressive neurodegenerative disease needs to be treated with …