Identification of Nitrogen Fixation Genes in Lactococcus Isolated from Maize Using Population Genomics and Machine Learning

SM Higdon, BC Huang, AB Bennett, BC Weimer - Microorganisms, 2020 - mdpi.com
Sierra Mixe maize is a landrace variety from Oaxaca, Mexico, that utilizes nitrogen derived
from the atmosphere via an undefined nitrogen fixation mechanism. The diazotrophic …

Monitoring the microbiome for food safety and quality using deep shotgun sequencing

KL Beck, N Haiminen, D Chambliss, S Edlund… - npj Science of …, 2021 - nature.com
In this work, we hypothesized that shifts in the food microbiome can be used as an indicator
of unexpected contaminants or environmental changes. To test this hypothesis, we …

Functional profiling of COVID-19 respiratory tract microbiomes

N Haiminen, F Utro, E Seabolt, L Parida - Scientific Reports, 2021 - nature.com
In response to the ongoing global pandemic, characterizing the molecular-level host
interactions of the new coronavirus SARS-CoV-2 responsible for COVID-19 has been at the …

Functional genomics platform, a cloud-based platform for studying microbial life at scale

EE Seabolt, G Nayar, H Krishnareddy… - IEEE/ACM …, 2020 - ieeexplore.ieee.org
The rapid growth in biological sequence data is revolutionizing our understanding of
genotypic diversity and challenging conventional approaches to informatics. With the …

Biological Machine Learning Combined with Campylobacter Population Genomics Reveals Virulence Gene Allelic Variants Cause Disease

DJDR Bandoy, BC Weimer - Microorganisms, 2020 - mdpi.com
Highly dimensional data generated from bacterial whole-genome sequencing is providing
an unprecedented scale of information that requires an appropriate statistical analysis …

WGS of intrauterine E. coli from cows with early postpartum uterine infection reveals a non-uterine specific genotype and virulence factors

A Garzon, C Basbas, C Schlesener, N Silva-del-Rio… - Mbio, 2024 - Am Soc Microbiol
Escherichia coli has been attributed to playing a major role in a cascade of events that affect
the prevalence and severity of uterine disease in cattle. The objectives of this project were to …

[PDF][PDF] Functional pathways in respiratory tract microbiome separate COVID-19 from community-acquired pneumonia patients

N Haiminen, F Utro, E Seabolt, L Parida - BioRxiv, 2020 - academia.edu
In response to the global pandemic of the last four months, progress has been made in
understanding the molecular-level host interactions of the new coronavirus SARS-Cov-2 …

Commensal or pathogen: computational vectorizing microbial genomes for de novo risk assessment and virulence feature discovery in Klebsiella pneumoniae

KL Beck, A Agarwal, AL Halpin, LC McDonald… - bioRxiv, 2024 - biorxiv.org
Bacterial pathogenicity has traditionally focused on gene-level content with experimentally-
confirmed functional properties. Hence, significant inferences are made based on similarity …