Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …

Pyroptosis refers to the process of gasdermin (GSDM)‐mediated programmed cell death
(PCD). Our understanding of pyroptosis has expanded beyond cells and is known to involve …

Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …

Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to
trigger a robust antitumor immune response. Platinum‐based chemotherapeutic agents can …

Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by
the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing …

Background Unraveling the mystery of cell death is one of the most fundamental progresses
of life sciences during the past decades. Regulated cell death (RCD) or programmed cell …

Simple Summary Chemotherapy has been widely used in clinic to treat various types of
tumors, although severe side effects have been the most critical limitation of this treatment …

Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell
death, which can be triggered by caspase-3 activation upon stimulation. Silenced GSDME …

Promoting innate immunity through pyroptosis induction or the cyclic GMP‐AMP synthase‐
stimulator of interferon gene (cGAS‐STING) pathway activation has emerged as a potent …

Pyroptosis is a programmed cell death mode discovered in recent years. It is caused by
inflammasomes and the perforation of Gasdermin family proteins, and results in the release …