Background: The gut is a target organ of thyroid hormone (TH) that exerts its action via the
nuclear thyroid hormone receptor α1 (TRα1) expressed in intestinal epithelial cells. THs are …

The maintenance of intestinal renewal and repair mainly depends on intestinal stem cells
(ISCs), which can also contribute to the growth of intestinal tumours. Hormones, which are …

Several studies emphasized the function of the thyroid hormones in stem cell biology. These
hormones act through the nuclear hormone receptor TRs, which are T3-modulated …

Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization,
with cancer stem cells (CSCs) responsible for tumor development, maintenance, and drug …

Post-embryonic acute developmental processes mainly allow the transition from one life
stage in a specific ecological niche to the next life stage in a different ecological niche …

Organoids offer a powerful model to study cellular self-organisation, the growth of specific
tissue morphologies in-vitro, and to assess potential medical therapies. However, the …

Background Central hypothyroidism (CH) is characterized by low T 4 levels and reduced
levels or bioactivity of circulating TSH. However, there is a lack of studies on CH-related …

The THRA gene, encoding the thyroid hormone nuclear receptor TRα1, is expressed in an
increasing gradient at the bottom of intestinal crypts, overlapping with high Wnt and Notch …

A pivotal role of thyroid hormones and their nuclear receptors in intestinal development and
homeostasis have been described, whereas their involvement in intestinal carcinogenesis is …

In the amphibian intestine during metamorphosis, most of the larval epithelial cells undergo
apoptosis, while a small number of the epithelial cells dedifferentiate into stem cells (SCs) …