Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches

W Wang, Z Huang, Y Huang, X Zhang, J Huang… - Advanced Drug Delivery …, 2022 - Elsevier
Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

Interactions of particulate matter and pulmonary surfactant: Implications for human health

F Wang, J Liu, H Zeng - Advances in colloid and interface science, 2020 - Elsevier
Particulate matter (PM), which is the primary contributor to air pollution, has become a
pervasive global health threat. When PM enters into a respiratory tract, the first body tissues …

Barrier or carrier? Pulmonary surfactant and drug delivery

A Hidalgo, A Cruz, J Pérez-Gil - European Journal of Pharmaceutics and …, 2015 - Elsevier
To consider the lung as a target for drug delivery and to optimise strategies directed at the
pulmonary route, it is essential to consider the role of pulmonary surfactant, a thin lipid …

Molecular modeling of nanoplastic transformations in alveolar fluid and impacts on the lung surfactant film

L Li, Y Xu, S Li, X Zhang, H Feng, Y Dai, J Zhao… - Journal of Hazardous …, 2022 - Elsevier
Airborne nanoplastics can be inhaled to threaten human health, but research on the inhaled
nanoplastic toxicity is in its infancy, and interaction mechanisms are largely unknown. By …

Is there an association between the level of ambient air pollution and COVID-19?

B Wang, H Chen, YL Chan… - American Journal of …, 2020 - journals.physiology.org
Epidemiological studies suggest that environmental factors (eg, air pollution) can influence
the spread and infectivity of coronavirus disease 2019 (COVID-19); however, very few …

Physicochemical properties of nanoparticles affecting their fate and the physiological function of pulmonary surfactants

Q Liu, J Guan, R Song, X Zhang, S Mao - Acta biomaterialia, 2022 - Elsevier
Pulmonary drug delivery has drawn great attention due to its targeted local lung action,
reduced side effects, and ease of administration. However, inhaled nanoparticles (NPs) …

[HTML][HTML] Pulmonary surfactant and nanocarriers: Toxicity versus combined nanomedical applications

A Hidalgo, A Cruz, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of
breathing, which coats and stabilizes the whole respiratory surface and possesses …

[HTML][HTML] Engineering of pulmonary surfactant corona on inhaled nanoparticles to operate in the lung system

M Falahati, A Hasan, HA Zeinabad, V Serpooshan… - Nano Today, 2023 - Elsevier
Exposure of inhaled nanoparticles (NPs) to the deep lung tissue results in the adsorption of
pulmonary surfactant (PSf) on the surface of NPs and the formation of a biomolecular …

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

L Herman, SC De Smedt, K Raemdonck - Journal of Controlled Release, 2022 - Elsevier
The COVID-19 pandemic has wielded an enormous pressure on global health care systems,
economics and politics. Ongoing vaccination campaigns effectively attenuate viral …

Lung surfactant-particles at fluid interfaces for toxicity assessments

E Guzmán, E Santini - Current opinion in colloid & interface science, 2019 - Elsevier
Lung surfactant is a complex mixture of lipids and proteins which plays a major role in the
respiratory cycle. This makes necessary to understand the effects of different external factors …