Microorganisms contend with numerous and unusual chemical threats and have evolved a
catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is …

The small multidrug resistance (SMR) family is composed of widespread microbial
membrane proteins that fulfill different transport functions. Four functional SMR subtypes …

MicroRNAs (miRNAs) play important roles in plant physiological activities. However, their
roles and molecular mechanisms in boosting plant immunity, especially through the …

The marvel of X-ray crystallography is the beauty and precision of the atomic structures
deduced from diffraction patterns. Since these patterns record only amplitudes, phases for …

The solute carrier (SLC) superfamily is the largest group of proteins responsible for the
transmembrane transport of substances in human cells. It includes more than 400 members …

Background Membrane proteins constitute a major group of proteins and are of great
significance as pharmaceutical targets, but underrepresented in the Protein Data Bank …

Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of
Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by …

Sulfur is in cellular components of bacteria and is, therefore, an element necessary for
growth. However, mechanisms by which bacteria satisfy their sulfur needs within a host are …

Nitrogen is an important element of Earth's atmosphere and exists in both inorganic and
organic forms. In nature, one form is to another through various biological and physical …

We describe an enhancement of traditional genomics-based approaches to improve the
success of structure determination of membrane proteins. Following a broad screen of …