NAFLD-associated HCC: progress and opportunities

D Geh, QM Anstee, HL Reeves - Journal of Hepatocellular …, 2021 - Taylor & Francis
Due to an increase in the obesity-associated metabolic syndrome of epidemic proportions,
nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of hepatocellular …

MASLD and the Development of HCC: Pathogenesis and Therapeutic Challenges

AGS Phoolchund, SI Khakoo - Cancers, 2024 - mdpi.com
Simple Summary Metabolic-dysfunction-associated steatotic liver disease (previously known
as non-alcoholic fatty liver disease) is a term for a range of liver conditions in which excess …

Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma

DW Jeong, JW Park, KS Kim, J Kim, J Huh… - Nature …, 2023 - nature.com
Palmitic acid (PA) is the most common fatty acid in humans and mediates palmitoylation
through its conversion into palmitoyl coenzyme A. Although palmitoylation affects many …

Robustness of radiomic features in CT images with different slice thickness, comparing liver tumour and muscle

L Escudero Sanchez, L Rundo, AB Gill, M Hoare… - Scientific reports, 2021 - nature.com
Radiomic image features are becoming a promising non-invasive method to obtain
quantitative measurements for tumour classification and therapy response assessment in …

Mechanistic action of cell cycle arrest and intrinsic apoptosis via inhibiting Akt/mTOR and activation of p38-MAPK signaling pathways in Hep3B liver cancer cells by …

A Abusaliya, SH Jeong, PB Bhosale, HH Kim, MY Park… - Nutrients, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) has a poor prognosis and a low survival rate. Drugs
without side effects are desperately needed since chemotherapy has a negative effect on …

Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma

A Muhammed, A D'Alessio, A Enica… - Expert Review of …, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) is the most common primary liver cancer and
fourth-leading cause of cancer death. While drug discovery to improve disease survival was …

On efficacy of microwave ablation in the thermal treatment of an early-stage hepatocellular carcinoma

B Radjenović, M Sabo, L Šoltes, M Prnova, P Čičak… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma accounts for around 75% of all liver cancers,
and represents the fourth most common cause of cancer-related deaths worldwide …

Tris (dibenzylideneacetone) dipalladium (0)(Tris DBA) abrogates tumor progression in hepatocellular carcinoma and multiple myeloma preclinical models by …

L Arora, CD Mohan, MH Yang, S Rangappa… - Cancers, 2021 - mdpi.com
Simple Summary STAT3 is a major oncogenic transcription factor that is constitutively
activated in many types of human cancers, including hepatocellular carcinoma (HCC) and …

Circular RNA hsa_circ_0061395 accelerates hepatocellular carcinoma progression via regulation of the miR-877-5p/PIK3R3 axis

Y Yu, L Bian, R Liu, Y Wang, X Xiao - Cancer cell international, 2021 - Springer
Background Circular RNA hsa_circ_0061395 (circ_0061395) has been reported to
accelerate the advancement of hepatocellular carcinoma (HCC). However, the regulatory …

Targeting anillin inhibits tumorigenesis and tumor growth in hepatocellular carcinoma via impairing cytokinesis fidelity

J Chen, Z Li, X Jia, W Song, H Wu, H Zhu, Z Xuan, Y Du… - Oncogene, 2022 - nature.com
Targeting cytokinesis can suppress tumor growth by blocking cell division and promoting
apoptosis. We aimed to characterize key cytokinesis regulator in hepatocellular carcinoma …