Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Rationale: Sleep disturbance during intensive care unit (ICU) admission is common and
severe. Sleep disturbance has been observed in survivors of critical illness even after …

Large numbers of individuals who have been infected with SARS-CoV-2, the virus
responsible for COVID-19, continue to experience a constellation of symptoms long past the …

Objectives To synthesize and evaluate current non-pharmacological sleep interventions for
critically ill adult patients in intensive care units and provide recommendations for future …

Sleep is important to health and well-being, and studies in healthy adults have
demonstrated that sleep deprivation impacts respiratory, immune, and cognitive function …

Objectives: To assess the efficacy of ramelteon in preventing delirium, an acute
neuropsychiatric condition associated with increased morbidity and mortality, in the …

Objective The relationships among sleep, circadian rhythm, and intensive care unit (ICU)-
acquired delirium are complex and remain unclear. This study aimed to examine the …

A wealth of data is available from electronic health records (EHR) that are collected as part
of routine clinical care in hospitals worldwide. These rich, longitudinal data offer an attractive …

We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19)
pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory …

Hospitalized patients frequently have disordered and poor-quality sleep due to a variety of
both intrinsic and extrinsic factors. These include frequent nighttime intrusions, insomnia …