The influence of radiation on bone and bone cells—differential effects on osteoclasts and osteoblasts

AJ Donaubauer, L Deloch, I Becker, R Fietkau… - International Journal of …, 2020 - mdpi.com
The bone is a complex organ that is dependent on a tight regulation between bone
formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes …

Intercellular communication of tumor cells and immune cells after exposure to different ionizing radiation qualities

S Diegeler, CE Hellweg - Frontiers in immunology, 2017 - frontiersin.org
Ionizing radiation can affect the immune system in many ways. Depending on the situation,
the whole body or parts of the body can be acutely or chronically exposed to different …

Targeted reduction of senescent cell burden alleviates focal radiotherapy‐related bone loss

A Chandra, AB Lagnado, JN Farr… - Journal of Bone and …, 2020 - academic.oup.com
Clinical radiotherapy treats life‐threatening cancers, but the radiation often affects
neighboring normal tissues including bone. Acute effects of ionizing radiation include …

Differences in responses to X-ray exposure between osteoclast and osteoblast cells

J Zhang, Z Wang, A Wu, J Nie, H Pei… - Journal of radiation …, 2017 - academic.oup.com
Radiation-induced bone loss is a potential health concern for cancer patients undergoing
radiotherapy. Enhanced bone resorption by osteoclasts and decreased bone formation by …

Effect of ionizing radiation after-therapy interval on bone: histomorphometric and biomechanical characteristics

PBF Soares, CJ Soares, PHJO Limirio… - Clinical Oral …, 2019 - Springer
Objectives This study aimed to evaluate the effects of radiotherapy on biomechanical,
histomorphometric, and microstructural characteristics of bone, in diverse periods, compared …

Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow

K Kumar, K Datta, AJ Fornace, S Suman - Heliyon, 2022 - cell.com
Low-LET photon radiation-induced persistent alterations in bone marrow (BM) cells are well
documented in total-body irradiated (TBI) rodents and also among radiotherapy patients …

Human mesenchymal stromal cells maintain their stem cell traits after high-LET particle irradiation–potential implications for particle radiotherapy and manned space …

A Rühle, D Ping, RL Perez, M Strack, S Brons, Q Yijia… - Cancer letters, 2022 - Elsevier
The influence of high-linear energy transfer (LET) particle radiation on the functionalities of
mesenchymal stromal cells (MSCs) is largely unknown. Here, we analyzed the effects of …

[HTML][HTML] Association between ambient beta particle radioactivity and lower hemoglobin concentrations in a cohort of elderly men

CLZ Vieira, E Garshick, D Alvares, J Schwartz… - Environment …, 2020 - Elsevier
Although ionizing radiation is known to have detrimental effects on red blood cells, the effect
of environmental radioactivity associated with ambient particulate matter (PM) is unknown …

Increased hematopoietic stem cells/hematopoietic progenitor cells measured as endogenous spleen colonies in radiation-induced adaptive response in mice …

B Wang, K Tanaka, Y Ninomiya… - Dose …, 2018 - journals.sagepub.com
The existence of radiation-induced adaptive response (AR) was reported in varied
biosystems. In mice, the first in vivo AR model was established using X-rays as both the …

MMR deficiency does not sensitize or compromise the function of hematopoietic stem cells to low and high LET radiation

R Patel, Y Qing, L Kennedy, Y Yan… - Stem cells …, 2018 - academic.oup.com
One of the major health concerns on long-duration space missions will be radiation
exposure to the astronauts. Outside the earth's magnetosphere, astronauts will be exposed …