The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

The outer surface of many archaea and bacteria is coated with a proteinaceous surface
layer (known as an S-layer), which is formed by the self-assembly of monomeric proteins …

The pathways that comprise cellular metabolism are highly interconnected, and alterations
in individual enzymes can have far-reaching effects. As a result, global profiling methods …

The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

The authors have developed a simple and highly efficient system for generating allelic
exchanges in both fast-and slow-growing mycobacteria. In this procedure a gene of interest …

The survival and persistence of Mycobacterium tuberculosis depends on its capacity to
manipulate multiple host defense pathways, including the ability to actively inhibit the death …

Protein translocation across the cytoplasmic membrane is an essential process in all
bacteria. The Sec system, comprising at its core an ATPase, SecA, and a membrane …

Macrophages play an essential role in the immune system by ingesting and degrading
invading pathogens, initiating an inflammatory response and instructing adaptive immune …

Tuberculosis remains a severe worldwide health threat. A thorough understanding of
Mycobacterium tuberculosis pathogenesis will facilitate the development of new treatments …

Surface proteins are critical in determining the identifying characteristics of individual
bacteria and their interaction with the environment. Because the structure of the cell surface …