Drug interactions occur when the efficacy or toxicity of a medication is changed by
administration of another substance. Pharmacokinetic interactions often occur as a result of …

Numerous medications, including drugs prescribed for noncardiac indications, can lead to
QT prolongation and trigger torsade de pointes. Although this complication occurs only …

OBJECTIVE: To describe the postmarketing safety data used in the risk assessment of
cisapride and to summarize the regulatory actions of the Food and Drug Administration …

One of the most common but difficult management problems in medicine is that of patients
who present with a paroxysmal loss of consciousness. All too often the underlying diagnosis …

Cisapride, a prokinetic agent, has been used for the treatment of a number of
gastrointestinal disorders, particularly gastro-oesophageal reflux disease in adults and …

Drug-induced long QT syndrome (diLQTS) is the phenomenon by which the administration
of drugs causes prolongation of cardiac repolarisation and leads to an increased risk of the …

Background Simvastatin is an inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐
CoA) reductase that is used as a cholesterol‐lowering agent and is metabolized by …

Background: Cisapride is a gastrointestinal prokinetic agent that is used worldwide in the
treatment of gastrointestinal motility-related disorders in premature infants, full-term infants …

Gastroesophageal reflux disease (GERD) is one of the most common diagnoses in a
gastroenterologist's practice. Gastroesophageal reflux describes the retrograde movement …

Abstract Introduction: The Bradford Hill criteria are a widely used, useful tool for the
assessment of biomedical causation. We have examined their application to …