Dementia in Africa: Current evidence, knowledge gaps, and future directions

RO Akinyemi, J Yaria, A Ojagbemi… - Alzheimer's & …, 2022 - Wiley Online Library
In tandem with the ever‐increasing aging population in low and middle‐income countries,
the burden of dementia is rising on the African continent. Dementia prevalence varies from …

Epidemiology of stroke in sickle cell disease

FJ Kirkham, IA Lagunju - Journal of Clinical Medicine, 2021 - mdpi.com
Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Hydroxyurea treatment and neurocognitive functioning in sickle cell disease from school age to young adulthood

AM Heitzer, J Longoria, V Okhomina… - British Journal of …, 2021 - Wiley Online Library
Neurocognitive impairment is common in sickle cell disease (SCD) and is associated with
significant functional limitations. In a cross‐sectional analysis, we examined the association …

The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian patients …

MB Rumaney, VJ Ngo Bitoungui, AA Vorster… - PloS one, 2014 - journals.plos.org
Background Co-inheritance of α-thalassemia was reported to be associated with a delayed
age of disease onset among Cameroonian Sickle Cell Anemia (SCA) patients. The present …

White matter integrity and processing speed in sickle cell anemia

H Stotesbury, FJ Kirkham, M Kölbel, P Balfour… - Neurology, 2018 - AAN Enterprises
Objective The purpose of this retrospective cross-sectional study was to investigate whether
changes in white matter integrity are related to slower processing speed in sickle cell …

Association of Variants at BCL11A and HBS1L-MYB with Hemoglobin F and Hospitalization Rates among Sickle Cell Patients in Cameroon

A Wonkam, VJ Ngo Bitoungui, AA Vorster, R Ramesar… - PloS one, 2014 - journals.plos.org
Background Genetic variation at loci influencing adult levels of HbF have been shown to
modify the clinical course of sickle cell disease (SCD). Data on this important aspect of SCD …

Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon

A Geard, GD Pule, B Chetcha Chemegni… - British journal of …, 2017 - Wiley Online Library
Micro‐albuminuria and glomerular hyperfiltration are primary indicators of renal dysfunctions
in Sickle Cell Disease (SCD), with more severe manifestations previously associated with …

Beta-globin gene haplotypes among cameroonians and review of the global distribution: is there a case for a single sickle mutation origin in Africa?

VJN Bitoungui, GD Pule, N Hanchard… - Omics: a journal of …, 2015 - liebertpub.com
Studies of hemoglobin S haplotypes in African subpopulations have potential implications
for patient care and our understanding of genetic factors that have shaped the prevalence of …

Psychosocial burden of sickle cell disease on parents with an affected child in Cameroon

A Wonkam, CZ Mba, D Mbanya… - Journal of genetic …, 2014 - Wiley Online Library
Abstract The chronicity of Sickle Cell Disease (SCD) could impair the quality of life of
caregivers. We performed a quantitative study to assess various indices of psychosocial …

Neurologic complications of sickle cell disease in Africa: a systematic review and meta-analysis

JJ Noubiap, MK Mengnjo, N Nicastro… - Neurology, 2017 - AAN Enterprises
Objective: To summarize prevalence data on the neurologic complications of sickle cell
disease (SCD) in Africa. Methods: We searched EMBASE, PubMed, and African Index …