Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …

Ion transport across the cell membrane mediated by channels and carriers participate in the
regulation of tumour cell survival, death and motility. Moreover, the altered regulation of …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

Abstract Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In
macrophages, transient stimulation of P2X7R activates several transport mechanisms and …

The TMEM16 family of membrane proteins is composed of both Ca2+-gated Cl− channels
and Ca2+-dependent phospholipid scramblases. The functional diversity of TMEM16s …

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …