Tailoring of chitosan through the involvement of its amino, acetamido, and hydroxy groups
can give derivatives of enhanced solubility and remarkable anticancer activity. The general …

Breast cancer is the second greatest cause of death among women worldwide; it comprises
a group of heterogeneous diseases that evolves due to uncontrolled cellular growth and …

Bacillus subtilis, a Gram‐positive, aerobic, endospore‐forming bacterium, was evaluated for
its probiotic potential in Indian major carp, Labeo rohita. Labeo rohita (15±2 g) were fed a …

Dysregulation of cell cycle progression is a hallmark of cancer cells. In recent years, efforts
have been devoted to the development of new therapies that target proteins involved in cell …

Abstract The METRIC study (NCT# 0199733) explored a novel antibody–drug conjugate,
glembatumumab vedotin (GV), targeting gpNMB that is overexpressed in~ 40% of patients …

Introduction: Microtubules play an important role in several cellular processes, particularly in
the formation of the mitotic spindle during the process of mitosis. These highly dynamic …

Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a
high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes …

This review describes the mechanism of action-inhibition of microtubules-and the most
important mechanisms of resistance for vinca alkaloids, taxanes and epothilones …

Abstract Treatment of metastatic breast cancer has substantially changed in the last
decades. Availability of new cytotoxics and targeted therapies as well as changes in …

Tubulin-targeting drugs, like taxanes and vinca alkaloids, are among the most effective
anticancer therapeutics used in the clinic today. Specifically, anti-microtubule cancer drugs …