Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …

The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …

Consciousness is a multidimensional phenomenon, but key dimensions such as awareness
and wakefulness have been described conceptually rather than neurobiologically. We …

Background Over the past 2 decades, the use of intravenous ketamine infusions as a
treatment for chronic pain has increased dramatically, with wide variation in patient …

Ketamine may have antidepressant properties, but its acute psychoactive effects complicate
successful masking in placebo-controlled trials. Here we present a single-center, parallel …

Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …

Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

Ketamine was introduced commercially in 1970 with the manufacturer's description as a
“rapidly acting, nonbarbiturate general anesthetic” and a suggestion that it would be useful …