CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular
homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary …

Abstract TMEM16A (ANO1), the pore-forming subunit of calcium-activated chloride
channels, regulates several physiological and pathophysiological processes such as …

Numerous essential physiological processes depend on the TMEM16A-mediated Ca2+-
activated chloride fluxes. Extensive structure–function studies have helped to elucidate the …

The many mechanisms governing NaCl absorption in the diverse parts of the renal tubule
have been largely elucidated, although some of them, as neutral NaCl absorption across the …

CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion
homeostasis in many different tissues. Among the nine mammalian CLC homologs, CLC-2 …

Key points The calcium‐activated chloride channel TMEM16A provides a pathway for
chloride ion movements that are key in preventing polyspermy, allowing fluid secretion …

ClC-2 is a voltage-dependent chloride channel that activates slowly at voltages negative to
the chloride reversal potential. Adenosine triphosphate (ATP) and other nucleotides have …

CLC-2 channels are dimeric double-barreled chloride channels that open in response to
hyperpolarization. Hyperpolarization activates protopore gates that independently regulate …

CLC-type chloride channels exhibit a unique double-barreled architecture with two
independently functioning ion conduction pathways, the so-called protopores. There exist …