Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders

J Spaas, L Van Veggel, M Schepers, A Tiane… - Cellular and Molecular …, 2021 - Springer
Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia

M Cuenod, P Steullet, JH Cabungcal, D Dwir… - Molecular …, 2022 - nature.com
A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

Glial cells in glaucoma: friends, foes, and potential therapeutic targets

MY García-Bermúdez, KK Freude… - Frontiers in …, 2021 - frontiersin.org
Glaucoma is the second leading cause of blindness worldwide, affecting~ 80 million people
by 2020 (,). The condition is characterized by a progressive loss of retinal ganglion cells …

β-aminoisobutyric acid, l-BAIBA, is a muscle-derived osteocyte survival factor

Y Kitase, JA Vallejo, W Gutheil, H Vemula, K Jähn, J Yi… - Cell reports, 2018 - cell.com
Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle
factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in …

Unraveling the link between mitochondrial dynamics and neuroinflammation

LG de Oliveira, YS Angelo, AH Iglesias… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory and neurodegenerative diseases are a major public health problem
worldwide, especially with the increase of life-expectancy observed during the last decades …

Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns

JG Jackson, MB Robinson - Glia, 2018 - Wiley Online Library
Astrocytes are the major glial cell in the central nervous system. These polarized cells
possess numerous processes that ensheath the vasculature and contact synapses …

Mitochondrial dynamics: a potential therapeutic target for ischemic stroke

X Zhou, H Chen, L Wang, C Lenahan, L Lian… - Frontiers in Aging …, 2021 - frontiersin.org
Stroke is one of the leading causes of death and disability worldwide. Brain injury after
ischemic stroke involves multiple pathophysiological mechanisms, such as oxidative stress …

Mechanisms for the maintenance and regulation of axonal energy supply

KA Chamberlain, ZH Sheng - Journal of neuroscience research, 2019 - Wiley Online Library
The unique polarization and high‐energy demand of neurons necessitates specialized
mechanisms to maintain energy homeostasis throughout the cell, particularly in the distal …

Mitochondria in myelinating oligodendrocytes: slow and out of breath?

N Meyer, JE Rinholm - Metabolites, 2021 - mdpi.com
Myelin is a lipid-rich membrane that wraps around axons and facilitates rapid action
potential propagation. In the brain, myelin is synthesized and maintained by …

Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo

MK Giacci, CA Bartlett, NM Smith, KS Iyer… - Journal of …, 2018 - Soc Neuroscience
Loss of function following injury to the CNS is worsened by secondary degeneration of
neurons and glia surrounding the injury and is initiated by oxidative damage. However, it is …