A new era of science and technology has emerged in pharmaceutical research with focus on
developing novel drug delivery systems for oral administration. Conventional dosage forms …

In recent years, controlled release of drugs has posed numerous challenges with the aim of
optimizing parameters such as the release of the suitable quantity of drugs in the right site at …

Nanocarriers have demonstrated great promise in the delivery of hydrophobic drugs
particularly to tumor spaces by enhanced permeability and retention (EPR) effects …

Background The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is
an approach most often used for extending nanomaterial circulation time, enhancing its …

Previous work by our group showed the possibility to reduce the toxicity of docetaxel upon
its encapsulation in polyaminoacid nanocapsules with a size of 200 nm. The objective of this …

Macrophages are pivotal cells of the innate immune system specialized in the phagocytosis
of foreign elements. Nanoparticles intentionally designed to target macrophages and …

Despite several reports have revealed the beneficial effect of co-administration of COX-2
inhibitors with aromatase inhibitors in managing postmenopausal breast cancer; no …

Lung cancer, associated with the up-regulated epidermal growth factor receptor (EGFR) led
to the development of EGFR targeted anticancer therapeutics. The biopolymeric …

Efficient oral administration of anticancer agents requires a nanocarrier to long survive in the
stomach, effectively penetrate across the small intestine, tightly retain the drug during …

Recently we reported for the first time a new type of nanocapsules consisting of an oily core
and a polymer shell made of a polyglutamic acid–polyethylene glycol (PEG–PGA) grafted …