Glucocorticoids: fuelling the fire of atherosclerosis or therapeutic extinguishers?
C MacLeod, PWF Hadoke, M Nixon - International Journal of Molecular …, 2021 - mdpi.com
Glucocorticoids are steroid hormones with key roles in the regulation of many physiological
systems including energy homeostasis and immunity. However, chronic glucocorticoid …
systems including energy homeostasis and immunity. However, chronic glucocorticoid …
[HTML][HTML] 'Browning'the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
P Aldiss, G Davies, R Woods, H Budge… - International journal of …, 2017 - Elsevier
Excess visceral adiposity, in particular that located adjacent to the heart and coronary
arteries is associated with increased cardiovascular risk. In the pathophysiological state …
arteries is associated with increased cardiovascular risk. In the pathophysiological state …
Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease
S Ramachandran, A Venugopal, VR Kutty… - Cardiovascular …, 2014 - Springer
Aims/hypothesis Cyclophilin A, an immunophilin is secreted from human monocytes
activated by high glucose. Given its role as an inflammatory mediator of vascular tissue …
activated by high glucose. Given its role as an inflammatory mediator of vascular tissue …
Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice
G Laryea, L Muglia, M Arnett, LJ Muglia - Frontiers in neuroendocrinology, 2015 - Elsevier
Negative feedback regulation of glucocorticoid (GC) synthesis and secretion occurs through
the function of glucocorticoid receptor (GR) at sites in the hypothalamic–pituitary–adrenal …
the function of glucocorticoid receptor (GR) at sites in the hypothalamic–pituitary–adrenal …
[HTML][HTML] PAI-1 and TNF-α profiles of adipose tissue in obese cardiovascular disease patients
Obesity as a leading preventable cause of death worldwide is closely linked to
cardiovascular disease (CVD). Plasma plasminogen activator inhibitor (PAI)-1, a potent …
cardiovascular disease (CVD). Plasma plasminogen activator inhibitor (PAI)-1, a potent …
High-fat/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice
JM Frick, OC Eller, RM Foright… - American Journal …, 2023 - journals.physiology.org
Exposure to stress early in life has been associated with adult-onset comorbidities such as
chronic pain, metabolic dysregulation, obesity, and inactivity. We have established an early …
chronic pain, metabolic dysregulation, obesity, and inactivity. We have established an early …
Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction
K Watanabe, T Kishino, J Sano, T Ariga, S Okuyama… - Heart and vessels, 2016 - Springer
Epicardial adipose tissue (EAT) is metabolically bioactive fat. The present study aimed to
clarify the relationship between EAT amount and early impairment of left ventricular (LV) …
clarify the relationship between EAT amount and early impairment of left ventricular (LV) …
Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis
HH Lin, JK Lee, CY Yang, YC Lien, JW Huang… - Cardiovascular …, 2013 - Springer
Background Symptoms of heart failure with preserved left ventricular systolic function are
common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an …
common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an …
11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases
D Kupczyk, R Studzińska, R Kołodziejska… - Journal of Clinical …, 2022 - mdpi.com
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
[PDF][PDF] Studzi nska
D Kupczyk - Clin. Med, 2022 - academia.edu
Glucocorticoids (GCs) belong to the group of steroid hormones. Their representative in
humans is cortisol. GCs are involved in most physiological processes of the body and play a …
humans is cortisol. GCs are involved in most physiological processes of the body and play a …