Bioorthogonal chemistry is widely used in biological systems and has been trialed in
patients, attracting a lot of attention in this century. Tetrazine-based bioorthogonal reactions …

C− H functionalization is one of the most convenient and powerful tools in the arsenal of
modern chemistry, deservedly nominated as the “Holy Grail” of organic synthesis. A frequent …

The direct, Pd-catalyzed ortho C–H methylation and fluorination of benzaldehydes have
been accomplished using commercially available orthanilic acids as transient directing …

Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group
via the first example of a Ag-mediated Liebeskind–Srogl cross-coupling. The attachment of …

Despite the growing application of tetrazine bioorthogonal chemistry, it is still challenging to
access tetrazines conveniently from easily available materials. Described here is the de …

Despite the immense potential of tetrazine bioorthogonal chemistry in biomedical research,
the in vivo performance of tetrazine probes is challenged by the inverse correlation between …

Selective introduction of fluorine into molecules by the cleavage of inert C− H bonds is of
central academic and synthetic interest, yet remains challenging. Given the central role of …

Since tetrazines are important tools to the field of bioorthogonal chemistry, there is a need
for new approaches to synthesize unsymmetrical and 3‐monosubstituted tetrazines …

Transition-metal-catalyzed C–H functionalizations have been extensively studied as atom-
and step-economical methods in organic synthesis. Oxidative C–H functionalization is one …

The straightforward access to a new class of aza‐polyaromatics is reported. Starting from
readily available fluorinated s‐tetrazine, a cyclization process with azide leads to the …