Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …

Combined pulmonary fibrosis and emphysema (CPFE) is a clinical syndrome characterized
by upper lobe emphysema and lower lobe fibrosis manifested by exercise hypoxemia …

Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic
variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of …

Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …

Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting
individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we …

Chronic obstructive pulmonary disease (COPD) often develops at an earlier age in women
than in men, with worse respiratory symptoms despite lower smoking exposure. However …

Rationale: Constantly exposed to the external environment and mutagens such as tobacco
smoke, human lungs have one of the highest somatic mutation rates among all human …

Rationale: Although many studies have examined gene expression in lung tissue, the gene
regulatory processes underlying emphysema are still not well understood. Finding efficient …

While many disease-associated single nucleotide polymorphisms (SNPs) are expression
quantitative trait loci (eQTLs), a large proportion of genome-wide association study (GWAS) …

Supported by NIH grants T32HL007427 and K08HL159318 (MM); NIH grants
K08HL136928, U01HL089856, and R01HL155749 and grant support from Bayer (BDH); US …