Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue
(AT) accompanied with alterations in the immune response that affects virtually all age and …

T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of
environmental factors and genetics, combining with a variety of epigenetic changes. Apart …

Obesity is a syndemia that promotes high expenditures for public health, and is defined by
the excess of adipose tissue that is classified according to its function and anatomical …

Obesity is characterized by an elevated amount of fat and energy storage in the adipose
tissue (AT) and is believed to be the root cause of many metabolic diseases (MDs). Obesity …

Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-
associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in …

The Brazilian biodiversity is one of the largest in the world, with about 41 000 species
cataloged within two global biodiversity hotspots: Atlantic Forest and Cerrado, the Brazilian …

Around 285 million people worldwide currently have type 2 diabetes and it is projected that
this number will be surpassed by 2030. Therefore, it is of the utmost importance to enhance …

Background Obesity is a multifactorial disease characterized by an enhanced amount of fat
and energy storage in adipose tissue (AT). Obesity appears to promote and maintain low …

Recent studies have investigated the control of adipose tissue expansion and inflammatory
process by microRNAs (miRNAs). These two processes are of great interest because both …