Intracellular signalling pathways have provided excellent resource for drug development
particularly in the development of cancer therapeutics. A wide variety of malignancies …

Abstract Heat shock protein (HSP) 90, an important component of the molecular chaperone
network, is closely concerned with cellular signaling pathways and stress response by …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse
cellular events such as cell survival, proliferation, differentiation, and death. As a pro …

XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be
relieved by IAP antagonists, such as Smac/DIABLO. IAP antagonist compounds (IACs) have …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-
promoting agents. The reciprocal activation between NF-κB and inflammatory cytokines …

Although hepatitis B virus (HBV) has been documented to cause hepatocellular carcinoma
(HCC), the exact role of HBV in the development of HCC remains enigmatic. Several …

Many food-derived phytochemical compounds and their derivatives represent a cornucopia
of new anticancer compounds. Despite extensive study of luteolin, the literature has no …

Introduction 3. NF-kappaB activation pathways 3.1. Protein components in the NF-kappaB
family 3.2. The pathways leading to NF-kappaB activation 4. NF-kappaB's cellular functions …